Circadian variation of ticagrelor-induced platelet inhibition in healthy adulty.

Fournier S, Guenat F, Fournier A, Alberio L, Bonny O, Bertaggia Calderara D, Bardy D, Lauriers N, Harbaoui B, Monney P, Pascale P, Eeckhout E, Muller O. Eur Heart J Cardiovasc Pharmacother. 2018 Jul 1;4(3):166-171

The circadian variation of platelet aggregation is well demonstrated. However, whether this has an impact on antiplatelet inhibition therapy is poorly documented. We aimed to observe whether ticagrelor-induced platelet inhibition follows a circadian rhythm.